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Talaroderxine D (compound 4) has biofilm inhibitory effect. Talaroderxine D shows antimicrobial activities against Bacillussubtilis and Staphylococcus aureus with MIC values of 2.1 and 8.3 μg/mL .
Massarigenin C is a compound that can be isolated from Massarina tunicata. Massarigenin C has inhibitory activity against Bacillussubtilis (ATCC 6051) .
Ziapin 2 is a molecular optomechanical light transducer. Ziapin 2 is an amphiphilic azobenzene with a strong non-covalent affinity to the plasma membrane. Ziapin 2 can be used to photo-modulate the membrane potential in cells of the Gram-positive bacterium Bacillussubtilis. Ziapin 2 enters the lipid membrane very rapidly (≈ 40 ns) .
5′-Deoxythymidine is a thymidine form which 5' position replaced with hydrogen. 5'-deoxy Thymidine is effective against Bacillussubtilis and Staphylococcus aureus. 5′-Deoxythymidine can be used as a research tool for antiviral and anticancer studies .
Maximin 15 is an antimicrobial peptide derived from the toad brain. Maximin 15 is active against Staphylococcus aureus, Escherichia coli and Bacillussubtilis, with MIC values of 9.4, 18.8, 75 μg/mL, respectively .
Maximin 28 is an antimicrobial peptide derived from the toad brain. Maximin 28 is active against Staphylococcus aureus, Escherichia coli and Bacillussubtilis, with MIC values of 4.7, 9.4, 75 μg/mL, respectively .
SF-C5-TPP is an potent mitochondria-targeted protonophoric uncoupler. SF-C5-TPP has significant proton transfer activity on model planar bilayer lipid membranes. SF-C5-TPP inhibits the growth of Bacillussubtilis with a MIC of 2 μM >[1].
Bsu DNA polymerase, Large fragment is a polymerase derived from Bacillussubtilis. Bsu DNA polymerase, Large fragment is a DNA isothermal amplification polymerase with chain replacement activity, which used in RPA recombinase polymerase amplification technology .
Kumbicin C is a bis-indolyl benzenoid compound from an Australian soil fungus, Aspergillus kumbius. Kumbicin C inhibits the growth of mouse myeloma cells and the Gram-positive bacterium Bacillussubtilis .
Globulol, antimicrobial sesquiterpene, is a natural product with antimicrobial activity. Globulol can be isolated from the fruits of Eucalyptus globulus Labill. Globulol shows antimicrobial activity against Xanthomonas vesicatoria and Bacillussubtilis, the IC50 value of 158.0 μg/mL and 737.2 μg/mL, respectively .
MraY-IN-1 (compound 12a) is a potent MraY inhibitor with an IC50 value of 140 μM. MraY-IN-1 has antimicrobial activity against Escherichia coli K12, Bacillussubtilis W23 and Pseudomonas fluorescens Pf-5 with MIC50s of 7 µg/mL, 12 µg/mL and 46 µg/mL, respectively. MraY-IN-1 can be used for researching anti-bacteria .
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillussubtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
N2-Acetylguanine is a C2-modified guanine. N2-Acetylguanine binds GR (guanine-guanine riboswitch) with an Kd value of 300 nM. N2-Acetylguanine modulate transcriptional termination. N2-Acetylguanine has the potential for the research of antimicrobial agent .
Pycnophorin significantly inhibits the growth of Bacillussubtilis and Staphyloccocus aureus with equal minimum inhibitory concentration (MIC) values of 25 μM.
Monascorubrin is purified from the mycelium of Monascus purpureus. Monascorubrin has significant antibiotic activities against Bacillussubtilis and Candida pseudotropicalis .
Betonicine (Achilleine), an alkaloid, has cell protectant activity. Betonicine protects Bacillussubtilis against extremes in osmolarity and growth temperatures .
Macatrichocarpin A is a flavanone with anti-bacterial activity. Macatrichocarpin A inhibits Bacillussubtilis with MIC value of 26.5 μM. Macatrichocarpin A can be isolated from the leaves of Macaranga trichocarpa .
Fraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillussubtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk .
Reutericyclin (Reutericycline), a unique tetramic acid, is an antibiotic produced by some strains of Lactobacillus reuteri. Reutericyclin (Reutericycline) exhibits a broad inhibitory spectrum including Lactobacillus spp., Bacillussubtilis, B. cereus, Enterococcus faecalis, Staphylococcus aureus, and Listeria innocua .
Blepharotriol is a phenolic triterpene that can be found in Maytenus blepharodes. Blepharotriol shows antimicrobial activity with a MIC value of 8-4 µg/ml for Bacillussubtilis. Blepharotriol shows cytotoxic activity with IC50s of 12.2, >20, >20 µM for HeLa, Hep-2, Vero cells, respectively .
Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillussubtilis .
Macrocarpal A (10-epi-Eucarobustol F) is an antibacterial agent, which can be isolated from the leaves of Eucalyptus macrocarpa. Macrocarpal A inhibits the growth of Bacillussubtilis PCI219 (minimum inhibitory concentration below 0.2 µM) and Staphylococcus aureus FDA209P (minimum inhibitory concentration is 0.4 µM) .
3-Methoxybenzamide (3-MBA), an inhibitor of ADP-ribosyltransferase (ADPRTs) and PARP, inhibits cell division in Bacillussubtilis, leading to filamentation and eventually lysis of cells . 3-Methoxybenzamide (3-MBA) enhances in vitro plant growth, microtuberization, and transformation efficiency of blue potato (Solanum tuberosum L. subsp. andigenum) .
Maximin 31 is an antimicrobial peptide derived from the toad brain. Maximin 31 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 37.5, 75 μg/mL, respectively .
Maximin 32 is an antimicrobial peptide derived from the toad brain. Maximin 32 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 9.4, 18.8 μg/mL, respectively .
Maximin 39 is an antimicrobial peptide derived from the toad brain. Maximin 39 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 18.8, 37.5 μg/mL, respectively .
Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml) .
(9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a nature product that could be isolated from the ethyl acetate extract of Cassonia barteri (Araliaceae) leaves. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol has antibacterial activity against Bacillussubtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata . (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillussubtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
Gageotetrin C is an antimicrobial peptide derived from the marine bacterium Bacillussubtilis. Gageotetrin C is more active against fungi (MIC value is 0.02-0.04 μM) .
Maximin 15 is an antimicrobial peptide derived from the toad brain. Maximin 15 is active against Staphylococcus aureus, Escherichia coli and Bacillussubtilis, with MIC values of 9.4, 18.8, 75 μg/mL, respectively .
Maximin 28 is an antimicrobial peptide derived from the toad brain. Maximin 28 is active against Staphylococcus aureus, Escherichia coli and Bacillussubtilis, with MIC values of 4.7, 9.4, 75 μg/mL, respectively .
Gageotetrin A is an antimicrobial peptide derived from the marine bacterium Bacillussubtilis. Gageotetrin A has antifungal activity, but none toxic to numerous human cancer cells .
Maximin 31 is an antimicrobial peptide derived from the toad brain. Maximin 31 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 37.5, 75 μg/mL, respectively .
Maximin 32 is an antimicrobial peptide derived from the toad brain. Maximin 32 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 9.4, 18.8 μg/mL, respectively .
Maximin 39 is an antimicrobial peptide derived from the toad brain. Maximin 39 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 18.8, 37.5 μg/mL, respectively .
Talaroderxine D (compound 4) has biofilm inhibitory effect. Talaroderxine D shows antimicrobial activities against Bacillussubtilis and Staphylococcus aureus with MIC values of 2.1 and 8.3 μg/mL .
Massarigenin C is a compound that can be isolated from Massarina tunicata. Massarigenin C has inhibitory activity against Bacillussubtilis (ATCC 6051) .
Maximin 15 is an antimicrobial peptide derived from the toad brain. Maximin 15 is active against Staphylococcus aureus, Escherichia coli and Bacillussubtilis, with MIC values of 9.4, 18.8, 75 μg/mL, respectively .
Maximin 28 is an antimicrobial peptide derived from the toad brain. Maximin 28 is active against Staphylococcus aureus, Escherichia coli and Bacillussubtilis, with MIC values of 4.7, 9.4, 75 μg/mL, respectively .
Kumbicin C is a bis-indolyl benzenoid compound from an Australian soil fungus, Aspergillus kumbius. Kumbicin C inhibits the growth of mouse myeloma cells and the Gram-positive bacterium Bacillussubtilis .
Globulol, antimicrobial sesquiterpene, is a natural product with antimicrobial activity. Globulol can be isolated from the fruits of Eucalyptus globulus Labill. Globulol shows antimicrobial activity against Xanthomonas vesicatoria and Bacillussubtilis, the IC50 value of 158.0 μg/mL and 737.2 μg/mL, respectively .
N2-Acetylguanine is a C2-modified guanine. N2-Acetylguanine binds GR (guanine-guanine riboswitch) with an Kd value of 300 nM. N2-Acetylguanine modulate transcriptional termination. N2-Acetylguanine has the potential for the research of antimicrobial agent .
Pycnophorin significantly inhibits the growth of Bacillussubtilis and Staphyloccocus aureus with equal minimum inhibitory concentration (MIC) values of 25 μM.
Monascorubrin is purified from the mycelium of Monascus purpureus. Monascorubrin has significant antibiotic activities against Bacillussubtilis and Candida pseudotropicalis .
Betonicine (Achilleine), an alkaloid, has cell protectant activity. Betonicine protects Bacillussubtilis against extremes in osmolarity and growth temperatures .
Macatrichocarpin A is a flavanone with anti-bacterial activity. Macatrichocarpin A inhibits Bacillussubtilis with MIC value of 26.5 μM. Macatrichocarpin A can be isolated from the leaves of Macaranga trichocarpa .
Fraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillussubtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk .
Reutericyclin (Reutericycline), a unique tetramic acid, is an antibiotic produced by some strains of Lactobacillus reuteri. Reutericyclin (Reutericycline) exhibits a broad inhibitory spectrum including Lactobacillus spp., Bacillussubtilis, B. cereus, Enterococcus faecalis, Staphylococcus aureus, and Listeria innocua .
Blepharotriol is a phenolic triterpene that can be found in Maytenus blepharodes. Blepharotriol shows antimicrobial activity with a MIC value of 8-4 µg/ml for Bacillussubtilis. Blepharotriol shows cytotoxic activity with IC50s of 12.2, >20, >20 µM for HeLa, Hep-2, Vero cells, respectively .
Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillussubtilis .
Macrocarpal A (10-epi-Eucarobustol F) is an antibacterial agent, which can be isolated from the leaves of Eucalyptus macrocarpa. Macrocarpal A inhibits the growth of Bacillussubtilis PCI219 (minimum inhibitory concentration below 0.2 µM) and Staphylococcus aureus FDA209P (minimum inhibitory concentration is 0.4 µM) .
Maximin 31 is an antimicrobial peptide derived from the toad brain. Maximin 31 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 37.5, 75 μg/mL, respectively .
Maximin 32 is an antimicrobial peptide derived from the toad brain. Maximin 32 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 9.4, 18.8 μg/mL, respectively .
Maximin 39 is an antimicrobial peptide derived from the toad brain. Maximin 39 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 18.8, 37.5 μg/mL, respectively .
Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml) .
(9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a nature product that could be isolated from the ethyl acetate extract of Cassonia barteri (Araliaceae) leaves. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol has antibacterial activity against Bacillussubtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata . (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
L-arabinose isomerase is a key enzyme in carbohydrate metabolism and plays a key role in catalyzing the conversion of L-arabinose to L-ribulose. This enzymatic activity is part of a broader biochemical pathway involved in the interconversion of sugars. L-arabinose isomerase Protein, Bacillus subtilis is the recombinant L-arabinose isomerase protein, expressed by E. coli , with tag free. The total length of L-arabinose isomerase Protein, Bacillus subtilis is 496 a.a., .
L-arabinose isomerase is a key enzyme in carbohydrate metabolism and plays a key role in catalyzing the conversion of L-arabinose to L-ribulose. This enzymatic activity is part of a broader biochemical pathway involved in the interconversion of sugars. L-arabinose isomerase Protein, Bacillus subtilis (His) is the recombinant L-arabinose isomerase protein, expressed by E. coli , with N-6*His labeled tag. The total length of L-arabinose isomerase Protein, Bacillus subtilis (His) is 496 a.a., .
Cephalosporin C deacetylase Protein, an esterase, selectively removes acetyl groups from substrates like acetylated xylose and cephalosporin C. Its catalytic activity excludes polymeric acetylated xylan and amide linkages, highlighting its nuanced, targeted deacetylation function. Cephalosporin C deacetylase Protein, Bacillus subtilis is the recombinant Cephalosporin C deacetylase protein, expressed by E. coli , with tag free. The total length of Cephalosporin C deacetylase Protein, Bacillus subtilis is 318 a.a., .
Sensor histidine kinase NatK Protein, a NatK/NatR system component, positively regulates natAB operon expression. It can phosphorylate NatR, mediating signal transduction in bacterial cells. The NatK/NatR system exemplifies a molecular mechanism for modulating gene expression, emphasizing the intricate regulatory processes orchestrated by sensor histidine kinases in bacterial signaling pathways. Sensor histidine kinase NatK Protein, Bacillus subtilis (Cell-Free, His) is the recombinant Sensor histidine kinase NatK protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of Sensor histidine kinase NatK Protein, Bacillus subtilis (Cell-Free, His) is 318 a.a., with molecular weight of 36.6 kDa.
The gucD protein is an important enzyme that catalyzes the irreversible ammonia removal of L-kynurenine to generate kynurenic acid (KA). This process is part of the tryptophan catabolic pathway and produces KA, known for its broad-spectrum antagonistic activity at excitatory amino acid receptors. gucD Protein, Bacillus subtilis is the recombinant gucD protein, expressed by E. coli , with tag free. The total length of gucD Protein, Bacillus subtilis is 487 a.a., .
The gucD protein is an important enzyme that catalyzes the irreversible ammonia removal of L-kynurenine to generate kynurenic acid (KA). This process is part of the tryptophan catabolic pathway and produces KA, known for its broad-spectrum antagonistic activity at excitatory amino acid receptors. gucD Protein, Bacillus subtilis (His, Strep) is the recombinant gucD protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of gucD Protein, Bacillus subtilis (His, Strep) is 487 a.a., .
YUAB is an important contributor to biofilm formation, self-polymerizing to form a hydrophobic layer with excellent stability and resistance to mechanical compression. YUAB is essential for complex colony structure, interacting synergistically with exopolysaccharides and TasA amyloid fibrils to facilitate biofilm matrix assembly. YUAB Protein, Bacillus subtilis (Cell-Free, His-SUMO) is the recombinant YUAB protein, expressed by E. coli Cell-free , with N-His, N-SUMO labeled tag. The total length of YUAB Protein, Bacillus subtilis (Cell-Free, His-SUMO) is 181 a.a., with molecular weight of ~35.3 kDa.
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